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Differential gene expression between wild type and Wnt11 mutant embryonic kidneys

ABSTRACT: The goal of this study was to identify changes in gene expression within nephron progenitors and the whole embryonic kidney between Wnt11 mutants and wild type animals. Wnt11 mutant kidneys have disorganized nephron progenitor niches. Ultimately, nephron endowment is reduced by 50% in Wnt11 mutants. Gene expression changes are minimal between mutant and wild type samples, suggesting Wnt11 may act through non-canonical, non-transcritional mechanisms to regulate kidney development.

ORGANISM(S): Mus musculus

PROVIDER: GSE118334 | GEO | 2018/10/31

REPOSITORIES: GEO

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