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Tri-4C: efficient and quantitative analysis of enhancer loops at hundred base pair resolution (Tri-4C)

ABSTRACT: Enhancer looping governs gene regulatory circuitry but is challenging to detect. Here we present Tri-4C, an ultrafine mapping method for distal chromatin contacts using triple restriction enzyme (RE) digestion. Tri-4C identifies enhancer loops that are undetectable by current single RE- based methods and reveals quantitative loop strengths in enhancer interaction networks underlying dynamic gene control. This multi-RE approach may be applied to general 3C-derived methods for accurate detection of enhancer loops.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119187 | GEO | 2020/08/28

REPOSITORIES: GEO

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Tri-4C: efficient and quantitative analysis of enhancer loops at hundred base pair resolution (ATAC-Seq)

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Project description:This SuperSeries is composed of the SubSeries listed below.

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