Transcriptomics

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Topoisomerase II inhibition involves characteristic chromosomal expression patterns: Doxorubicin study


ABSTRACT: A variety of important anticancer drugs kill cells by increasing cellular levels of topoisomerase II-DNA cleavage complex. The anthracycline anticancer drug doxorubicin forms a stable ternary complex with DNA and topoisomerase IIa, thereby inhibiting the normal function of the enzyme. In this study we found genes regulated by doxorubicin - induced and repressed - to be located much closer to each other than genes distributed randomly all over the genome (< 100 kbp). Keywords: Doxorubicin-treated human hepatocytes versus non-treated human hepatocytes

ORGANISM(S): Homo sapiens

PROVIDER: GSE11940 | GEO | 2008/10/01

SECONDARY ACCESSION(S): PRJNA109251

REPOSITORIES: GEO

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