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Small RNA sequencing of LA-N-2 cells exposed to ciliary neurotrophic factor for 30/60 min and 2/4 days

ABSTRACT: To examine the impact of gp130-mediated, pro-cholinergic neurokine intervention on the small RNA systems in human neuronal cells, we exposed cultured LA-N-2 cells to 100 ng/ml ciliary neurotrophic factor (CNTF). RNA sequencing of time points at 30/60 minutes and 2/4 days of CNTF exposure shows a significant response and an “immediate early”/”long term” dichotomy in differentially expressed miRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE120520 | GEO | 2019/10/15

REPOSITORIES: GEO

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Small RNA sequencing of LA-N-2 and LAN-5 cells exposed to ciliary neurotrophic factor for 30/60 min and 2/4 days

Project description:To examine the impact of gp130-mediated, pro-cholinergic neurokine intervention on the small RNA systems in female and male human neuronal cells, we exposed cultured LA-N-2 cells (female) to 100 ng/ml ciliary neurotrophic factor (CNTF), and LAN-5 cells (male) to 10 ng/ml CNTF. RNA sequencing of time points at 30/60 minutes and 2/4 days of CNTF exposure shows a significant response and an “immediate early”/”long term” dichotomy in differentially expressed miRNAs.

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Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration

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Ciliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells

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2011-08-31 | E-GEOD-27195 | biostudies-arrayexpress

Small RNA sequencing of LA-N-2 cells exposed to ciliary neurotrophic factor for 30/60 min and 2/4 days

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Ciliary neurotrophic factor induces genes associated with inflammatory response and gliosis in the retina: A gene profiling study of flow-sorted, Muller (glial) cells

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Cellular responses in the airway ciliary microenvironment from mouse models of primary ciliary dyskinesia with central pair apparatus defects

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