Genomics

Dataset Information

0

MicroRNA profiles in red drum (Sciaenops ocellatus) larvae exposed to Deepwater Horizon oil


ABSTRACT: Purpose:To help identify molecular regulatory mechanisms of developmental toxicity for fish exposed to Deepwater Horizon (DWH) oil, microRNA profiles in red drum larvae exposed to different DWH oils (source/mass and artificially weathered oil) were evaluated using High Throughput Sequencing (HTS). Methods:Total microRNA profiles of 48 hpf red drum larvae after source oil (0.135%, 0.27%, and 0.54%) and slick oil (1.25%, 2.5% and 5%) exposure were generated by deep sequencing, in triplicate, using Illumina NextSeq 500. Results: Source and slick oil significantly dysregulated the expression of miR-18a, miR-27b, and miR-203a across all exposure concentrations. The target genes of these miRNAs were predominantly involved in the neuro-cardio system development processes and associated key signaling pathways such as axonal guidance signaling, CREB signaling in neurons, synaptic long-term potentiation pathway, calcium signaling and role of NFAT in cardiac hypertrophy.

ORGANISM(S): Sciaenops ocellatus

PROVIDER: GSE120670 | GEO | 2019/01/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-01-09 | GSE119934 | GEO
2017-11-14 | GSE90113 | GEO
2019-02-20 | GSE116711 | GEO
2016-07-07 | E-GEOD-79675 | biostudies-arrayexpress
2016-07-07 | GSE79675 | GEO
2019-02-20 | GSE116639 | GEO
2017-12-04 | GSE102966 | GEO
| PRJNA494063 | ENA
| PRJNA494060 | ENA
| PRJNA354426 | ENA