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An enhancer in the middle of the Igκ locus orchestrates nuclear architecture to generate a diverse antigen receptor repertoire

ABSTRACT: Purpose:The goal of this study is to assess transcriptome profile in the absence of a potent enhancer located in the V gene region of the Igκ locus in cell lines and mice Methods: RNAseq from CD19+ cells from B6.RAG1-/- and E88-/-.RAG1-/- mice. RNAseq from 445.3, wild-type (WT) and E88-/-, pro-B cell lines

ORGANISM(S): Mus musculus

PROVIDER: GSE121224 | GEO | 2018/11/15

REPOSITORIES: GEO

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A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire.

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