Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiling of chronic hepatitis B induced HCC and adjacent-normal tissues

ABSTRACT: Differential gene expression analysis between chronic hepatitis B induced HCC and adjacent Normal tissues using Affymetrix gene arrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121248 | GEO | 2018/10/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profiling of chronic hepatitis B induced HCC and adjacent-normal tissues

Project description:Gene expression profiling of chronic hepatitis B induced HCC and adjacent-normal tissues

| PRJNA496477 | ENA

Gene expression profiling of PBMC from normal individuals, chronic hepatitis B carriers and hepatocellular carcinoma patients

2014-06-04 | GSE58208 | GEO

Gene expression profiling of PBMC from normal individuals, chronic hepatitis B carriers and hepatocellular carcinoma patients

Project description:Aberrant gene expression analysis between peripheral blood mononuclear cell (PBMC) samples from healthy individuals and patients with chronic hepatitis B carriers and HCC were identified using Affymetrix gene arrays.M-BM- Peripheral blood mononuclear cell (PBMC) from healthy individuals, patients with patients with chronic hepatitis B carriers and HCC were isolated and total RNA was extracted for Affymetrix gene microarray analysis.

2014-06-04 | E-GEOD-58208 | biostudies-arrayexpress

Methylation in Taiwanese HCC tumor and adjacent tissues

Project description:We analyzed tumor and adjacent non-tumor tissues from 62 Taiwanese HCC cases using Illumina HumanMethylation 27 chips. After Bonferroni adjustment, a total of 2,324 CpG sites significantly differed in methylation level, with 684 CpG sites significantly hypermethylated and 1,640 hypomethylated in tumor compared to non-tumor tissues. Array data were validated with pyrosequencing in a subset of 5 of these genes; correlation coefficients ranged from 0.92 to 0.97. 62 tumor and 62 adjacent non tumor tissues

2012-05-15 | E-GEOD-37988 | biostudies-arrayexpress

Expression data from paired human primary HCC tissues and adjacent non-cancerous liver tissues.

Project description:Hepatic cirrhosis or advanced fibrosis caused by chronic hepatitis may be the main risk factor contributing to the occurrence of HCC. Growing clinical evidence show that patients with hepatic cirrhosis or advanced fibrosis may have a 7-fold higher incidence rate of HCC than those without, suggesting a crucial role of inflammation-carcinogenesis malignant transformation in HCC development and progression. We used microarrays to detail the global programme of gene expression underlying inflammation-carcinogenesis malignant transformation in HCC and identified distinct classes of up-regulated and down-regulated genes during this process

2021-02-12 | GSE166163 | GEO

RNA-Seq data of tumors and paired adjacent tissues from 15 HCC patients

Project description:Hepatitis B virus (HBV) mutations promote the occurrence of hepatocellular carcinoma (HCC). However, their association with postoperative prognosis remains obscure. Here, we aimed to characterize the evolution of HBV in different sources and identify viral mutation pattern that facilitates postoperative prognosis of HCC.

2022-12-01 | GSE135631 | GEO

HCC prediction after clearance of HCV in chronic hepatitis C II

Project description:We attempted to development prediction methods for hepatocellular carcinoma (HCC) in chronic hepatitis C patients who have been successfully treated by anti-viral therapy. 2565 miRNAs in 139 exosome specimens were analyzed.

2020-01-24 | GSE119159 | GEO

HCC prediction after clearance of HCV in chronic hepatitis C I

2020-01-24 | GSE119156 | GEO

Transcription profiling of human liver samples from subjects with hepatitis C virus (HCV), HCV-HCC, or normal liver

Project description:The role of chronic hepatitis C virus (HCV) in the pathogenesis of HCV-associated hepatocellular carcinoma (HCC) is not completely understood, particularly at the molecular level. We studied gene expression in normal, pre-malignant (cirrhosis), and tumor (HCC) liver tissues using Affymetrix GeneChips. Experiment Overall Design: Liver tissue samples were obtained from patients waiting for liver transplantation at one of the GR2HCC Centers. Additionally, normal liver and tumor samples were also obtained from the Liver Tissue Cell Distribution System. For each sample, RNA was extracted and hybridized to an Affymetrix GeneChip.

2009-01-18 | E-GEOD-14323 | biostudies-arrayexpress