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Genomic binding profile of Junctophilin 2 N-terminal truncate (JP2NT) and the effect of JP2NT overexpreesion on cardiac transcriptional reprogramming in response to Transverse Aortic Banding

ABSTRACT: Calpain-mediated cleavage transfroms the full-length JP2 from a structural protein into a transcriptional regulator (JP2NT). We used RNA-seq to reveal the effect of JP2NT overexpression on cardiac transcriptional reprogramming induced by left ventricular pressure overload using transverse aortic banding in mice. We used ChIP-seq to reveal the genomic binding pattern of JP2NT. Additional ChIP-seq analyses against TBP and MEF2C were performed to reveal whether JP2NT overexpression affects endogeneous binding of TBP and MEF2C.

ORGANISM(S): Mus musculus

PROVIDER: GSE121546 | GEO | 2019/01/31

REPOSITORIES: GEO

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