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Transcriptomics and chromatin accessibility analysis of MLL-AF9 early responses in mouse bone marrow cells

ABSTRACT: We investigated early changes of gene expressions and chromatin accessibilities in hematopoietic stem and progenitor cells (HSPCs) in response to MLL-AF9 oncogene expressions. Using RNA-Seq and ATAC-Seq, we analyzed HSPCs briefly exposed to MLL-AF9 for one or two days. Such analysis addressed the initial changes during malignant transformation, and provided insights into the primary functions of MLL-AF9 oncogene.

ORGANISM(S): Mus musculus

PROVIDER: GSE121768 | GEO | 2019/10/12

REPOSITORIES: GEO

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RNA-seq profiling of murine Tet-off MLL-AF9; NRAS acute myeloid leukemia at different timepoints upon doxycycline-induced MLL-AF9 down-regulation.

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