Src modulates its oncogenic signaling via regulation of miRNA-129-3p [mRNA]
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ABSTRACT: To address the molecular mechanisms underlying c-Src-induced cell transformation, we previously developed a model system using Csk-deficient fibroblasts that can be transformed by wild-type c-Src. In this study, we applied this system for the analysis of the potential contribution of mRNA and miRNA to c-Src-induced cell transformation. We found miR-129-3p was downregulated in c-Src-induced cell transformation in a Dox-inducible expression system via c-Src, c-Yes, and Fer.
ORGANISM(S): Mus musculus
PROVIDER: GSE121852 | GEO | 2019/12/08
REPOSITORIES: GEO
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