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RNA-seq data for: A conserved mito-cytoplasmic translational balance links two longevity pathways

ABSTRACT: Slowing down mRNA translation in either the cytoplasm or the mitochondria are both conserved longevity mechanisms. Here, we found a non-interventional natural correlation of mitochondrial and cytoplasmic ribosomal proteins when looking at mouse population genetics, suggesting a mito-cytoplasmic translational balance. Additionally, inhibiting mitochondrial translation in C. elegans in turn reduced cytoplasmic translation and repressed growth pathways while upregulating stress responses at both proteome and transcriptome levels. This coordinated repression of cytoplasmic translation is dependent on the atf-5/Atf4 transcription factor and is conserved in mammalian cells upon inhibiting mitochondrial translation pharmacologically with the antibiotic doxycycline. Lastly, extending this to a mammalian setting using doxycycline-treated germ-free mice, we found repressed cytoplasmic translation and ribosomal proteins in liver. These data demonstrate that inhibiting mitochondrial translation initiates a signaling cascade leading to coordinated repression of cytoplasmic translation, unlike previously described unidirectional cyto-to-mito translational communication in yeast, which can be targeted to promote healthy aging.

ORGANISM(S): Caenorhabditis elegans Mus musculus

PROVIDER: GSE122097 | GEO | 2019/12/11

REPOSITORIES: GEO

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The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs

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RNA-seq data for: A conserved mito-cytoplasmic translational balance links two longevity pathways

Project description:RNA-seq data for: A conserved mito-cytoplasmic translational balance links two longevity pathways

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