Genomics

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Analysis of miRNA expression patterns in tetracycline (Tet) inducible Scl/tTA-BCR/ABL (Scl-BA) transgenic mouse hematopoietic stem-progenitor cells.


ABSTRACT: To further define the roles of miRNAs in the pathogenesis of CML, we have employed miRNA microarray expression profiling as a discovery platform to identify miRNAs with the potential to drive or accelerate CML progression. Hematopoietic stem-progenitor cells miRNA profiles of BA mice after BCR/ABL expression induced for 0 week and 3 weeks were generated by miRNA microarray. Expression of six miRNAs (miR-126a-3p, miR-130a-3p,miR-142a-5p, miR-142a-3p, miR-29c-3p and miR-30c-5p) from this signature was quantified in the same RNA samples by real-time PCR, confirming low variability in BCR/ABL expressing cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE122432 | GEO | 2021/06/30

REPOSITORIES: GEO

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