Transcriptome of a long-lived mutant nematode with severe mitochondrial deficiency

ABSTRACT: Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we analyze the transcriptome of a well established model for mitochondrial deficiency, gas-1(fc21) mutant nematodes, which when placed in a genetic context of IIS inhibition, undergo metabolic rewiring leading to a massive lifespan extension

OTHER RELATED OMICS DATASETS IN: PXD011851 PXD011859 MTBLS794

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE122902 | GEO | 2019/02/12

REPOSITORIES: GEO