Differential expression of antiviral factors in H9c2 cells overexpressing Cacnb4 of the Cav1.2 channel
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ABSTRACT: L-type voltage gated Ca channels play a critical role in E-C coupling in cardiac muscle. alpha1C is associated with beta auxiliary subunits (b1-b4), which regulate cardiac Ca channel gating properties. Here we report a preliminary exploratory study suggesting a novel role of beta4 subunit in heart. We observed that overexpression of beta4 subunit increases the expression of a wide variety of endogenous genes related to antiviral activity. This includes genes in the downstream signalling of RIG-1 pathway such as RIG-1, Irf7 and Ifitm3. The increase expression of these factors may have an antiviral protective role against infection.
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE122950 | GEO | 2018/11/27
REPOSITORIES: GEO
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