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Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy

ABSTRACT: Findings suggest that PPARalpha plays a decisive role in the development of hypertrophy, affecting the functional outcome of the heart. Unfortunately, information on the nature of PPARalpha-dependent processes in cardiac hypertrophy is fragmentary and incomplete. The primary aim of this study was to identify the processes and signaling pathways regulated by PPARalpha in hearts challenged by a chronic pressure overload by means of whole genome transcriptomic analysis. Second, we wanted to gain insight how PPARalpha modulates the identified processes, e.g. by trans-activation or by trans-repression. Keywords: 28 days of TAC

ORGANISM(S): Mus musculus

PROVIDER: GSE12337 | GEO | 2008/08/06

SECONDARY ACCESSION(S): PRJNA113231

REPOSITORIES: GEO

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Transcription profiling of mouse mutant PPARalpha-/- mice vs wild type after pressure overload generated cardiac hypertrophy

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