MEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling
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ABSTRACT: Analysis of bone-marrow derived macrophages (BMDMs) stimulated with single or combinatorial TLR agonist and MEK1/2 inhibitor in wild-type and Irf1-/- macrophages. Results provide insights into the versatile but yet uncharacterized roles of IRF1 in TLR-MEK1/2-ERK MAPK signaling.
ORGANISM(S): Mus musculus
PROVIDER: GSE123512 | GEO | 2018/12/28
REPOSITORIES: GEO
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