Reconstruction of transcriptional regulatory networks of Fis and H-NS in Escherichia coli from genome wide data analysis
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ABSTRACT: Fis and H-NS are two well-known NAPs in proteobacteria which play crucial role in both genome organization and gene regulation. However, the global effects of Fis and H-NS on gene expression remain unclear. Here, to decipher transcriptional regulatory roles of Fis and H-NS we have performed RNA-sequencing to compare gene expression between the wild-type E. coli and its knockout mutants for fis and hns. We integrated our RNA-seq results with publically available ChIP-seq data to define direct and indirect regulation by Fis and H-NS. The regulatory networks thus provide a comprehensive view of coordinated regulatory roles for these important nucleoid-associated proteins.
ORGANISM(S): Escherichia coli
PROVIDER: GSE123554 | GEO | 2018/12/11
REPOSITORIES: GEO
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