Genomics

Dataset Information

0

P63 cooperates with CTCF to modulate chromatin accessibility and architecture in skin keratinocytes


ABSTRACT: Here we integrated multi-omics profiles including transcriptomics, DNA accessibility and capture Hi-C data to explore how p63 shapes local chromatin architecture in skin keratinocytes isolated from EEC syndrome patients. Surprisingly, we observed decreased chromatin accessibility in a number of DNA looping nodes which were co-mediated by p63 and CTCF. Our findings not only identified a new aspect of the bookmark function of p63, but also shed light on the disease mechanism underlined p63 dysfunction. Therefore, we propose p63 as a spatial genome organizer by modulating a subset of DNA loops with CTCF and therefore fine-tuning transcription programs required for skin keratinocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123711 | GEO | 2019/06/21

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| phs001737 | dbGaP
| PRJNA509627 | ENA
2024-02-10 | GSE252023 | GEO
2022-10-25 | GSE188447 | GEO
2008-06-16 | E-GEOD-8646 | biostudies-arrayexpress
2012-06-07 | E-GEOD-32061 | biostudies-arrayexpress
2007-08-02 | GSE8646 | GEO
2013-02-26 | GSE34862 | GEO
2015-11-12 | GSE67382 | GEO
2013-02-26 | E-GEOD-34862 | biostudies-arrayexpress