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RNA-seq data for non-targeting siRNA and lncRNA LOL siRNA transfection in MCF-7 cells

ABSTRACT: To elucidate which portions of signaling pathways LOL influences in luminal breast cancer, RNA-seq analysis was performed in siLOL MCF-7 cell lines. Eight hundred eighty-three downregulated genes and 1182 upregulated genes (fold change ≥1.5) were detected after LOL knockdown. Gene set enrichment analysis (GSEA) of hallmarks indicated that the gene sets related to DNA_Repair, G2M_Checkpoint, E2F_Targets and MYC_Targets were positively correlated with LOL downregulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123820 | GEO | 2018/12/14

REPOSITORIES: GEO

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