Transcriptomics

Dataset Information

0

The Effect of Chronic Hypoxia on Cardiac Gene Expression in Rattus Norvegicus


ABSTRACT: To explore the gene expression prolife in the chroniclly hypoxic myocardium, 8 rats were divided randomly into normoxic (n=4) or chroniclly hypoxic (n=4) group, and were exposed to room air (21% O2) or continued hypoxia (10% O2) for 4 weeks. Heart tissues were collected and RNA sequencing was applied to detect the overall gene expression prolife. Genes with adjusted P-value ≤0.01 (corrected by Benjamini-Hochberg) and |log2_ratio|≥0.585 are identified as differentially expressed genes. RNA sequencing identified a total of 2014 gene with statistical significances, among which 1260 genes were significantlly increased and 754 genes were significantlly decreased. The results showed that gene expression profiling was perturbed in chronically hypoxic myocardium.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE123948 | GEO | 2020/12/17

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| S-EPMC9277659 | biostudies-literature
| S-EPMC7145424 | biostudies-literature
| S-EPMC7161169 | biostudies-literature
2016-08-18 | GSE81418 | GEO
| S-EPMC8319288 | biostudies-literature
| S-EPMC8858310 | biostudies-literature
2015-01-01 | GSE58692 | GEO
| S-EPMC3840628 | biostudies-literature
| S-EPMC6913977 | biostudies-literature
| S-EPMC9307595 | biostudies-literature