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Expression data from bone marrow of human subjects (6 primary myelofibrosis, 3 essential thrombocythemia and 8 controls)

ABSTRACT: Fibrosis is the hallmark of primary myelofibrosis, a disease characterized by increased TGF-β bioavailability in bone marrow and spleen from both patients and mouse models. The aim of this study was to verify the role of TGF-β signaling in comparison to essential thrombocythemia and non-diseased control by using human bone marrow. We used RNA microarrays to investigate gene expression in bone marrow and identified distinct classes of up/down-regulated genes during this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124281 | GEO | 2018/12/22

REPOSITORIES: GEO

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Expression data from bone marrow of human subjects (3 essential thrombocythemia, 2 primary myelofibrosis, and 3 controls)

Project description:Fibrosis is the hallmark of primary myelofibrosis, a disease characterized by increased TGF-β bioavailability in bone marrow and spleen from both patients and mouse models. The aim of this study was to verify the role of TGF-β signaling in comparison to essential thrombocythemia and non-diseased control by using human bone marrow. We used RNA microarrays to investigate gene expression in bone marrow and identified distinct classes of up/down-regulated genes during this process.

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Expression data from bone marrow of human subjects (6 primary myelofibrosis, 3 essential thrombocythemia and 8 controls)

Project description:Expression data from bone marrow of human subjects (6 primary myelofibrosis, 3 essential thrombocythemia and 8 controls)

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Expression data from bone marrow of human subjects (3 essential thrombocythemia, 2 primary myelofibrosis, and 3 controls)

Project description:Expression data from bone marrow of human subjects (3 essential thrombocythemia, 2 primary myelofibrosis, and 3 controls)

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Gene expression data from CD34+ BMMCs/PBMCs from JAK2V617F positive MPN patients vs. Healthy controls

Project description:Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) consist of primary myelofibrosis (PMF), polycythemia vera (PV), essential thrombocythemia (ET) and seconday myelofibrosis (pPV-MF or pET-MF) In this dataset, we compare the gene expression data of bone marrow (BM) or peripheral blood (PB) mononuclear cells of CD34+ cells from JAK2V617F mutated patients vs. healthy donors

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Gene expression data from CD34+ BMMCs/PBMCs from MPN patients vs. healthy controls

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Inhibition of CDK6 using Palbociclib in combination with Ruxolitinib markedly improves myelofibrosis in murine models

Project description:Myelofibrosis (MF) is a deadly blood neoplasia that presents the worst prognosis among myeloproliferative neoplasms (MPN). Expression of CDK6 is significantly elevated in MPN/MF hematopoietic progenitor cells. In this study, we investigated the efficacy of CDK4/6 inhibitor Palbociclib alone or in combination with Ruxolitinib in Jak2V617F and MPLW515L murine models of MF. Treatment of Palbociclib alone significantly reduced leukocytosis, splenomegaly and inhibited bone marrow fibrosis in Jak2V617F and MPLW515L mouse models of MF. Combined treatment of Palbociclib and Ruxolitinib resulted in normalization of peripheral blood leukocyte counts, marked reduction of spleen size and abrogation of bone marrow fibrosis in murine models of MF. Mechanistically, we show that Palbociclib treatment or depletion of CDK6 inhibits Aurora kinase, NF-κB and TGF-β signaling pathways in Jak2V617F mutant hematopoietic cells. Overall, our data suggest that Palbociclib in combination with Ruxolitinib may have therapeutic potential for treatment of MF.

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Gene expression data of bone marrow mesenchymal stromal cells in myelofibrosis

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Real-time quantitative PCR analysis of murine bone marrow cells

Project description:TGF-β1 signaling pathway of bone marrow of the Gata1low mouse model of myelofibrosis

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Project description:In order to comprehensively characterize the cellular constituents of the bone marrow microenvironment in primary myelofibrosis, single-cell RNA sequencing was performed on bone marrow stromal cells isolated from mice transplanted with MPLW515L-transduced hematopoietic cells.

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