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DHX9 and NPM1 silencing RNA-seq

ABSTRACT: In our study, we valided DHX9 and NPM1 interact with KIMAT1, whereas DHX9 also interacts with HIF1A-As2. DHX9 is a highly conserved DEAD-box protein expressed in the nucleus and the cytoplasm, involved in many processes including transcriptional activation, miRNA biogenesis and tumor cell maintenance. NPM1 is predominantly localized in the nucleoplasm, where it associates with active RNA polymerase II and transcriptionally activates genes involved in cancer. We silenced DHX9 and NPM1 and performed RNA-seq to examine the dysregulated genes by DHX9 and NPM1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124626 | GEO | 2020/12/17

REPOSITORIES: GEO

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DHX9 and NPM1 silencing RNA-seq

Project description:DHX9 and NPM1 silencing RNA-seq

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