Genomics

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MiRNA expression profile is related to vestibular schwannoma growth rate


ABSTRACT: Tumor miRNA expression is related to the growth rate of sporadic vestibular schwannomas. Rapid tumor growth is associated with deregulation of several miRNAs, including up-regulation of miR-29abc, miR-19, miR-340-5p, miR-21 and miR-221 and down-regulation of miR-744 and let-7b. Gene ontologies affected by the deregulated miRNAs included neuron development and differentiation, gene silencing and negative regulation of various biological processes, including cellular and intracellular signalling and metabolism. We used microarray to determine the miRNA expresison in vestibular schwannoma their relation to the growth rate.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE124717 | GEO | 2019/01/08

REPOSITORIES: GEO

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