Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome profile of peritoneal lavage in response to adjuvants Alum and the polysaccharide from the roots of Actinidia eriantha (AEPS)

ABSTRACT: Analysis of peritoneal lavage from BALB/c mice 2 hours after intraperitoneal injection with PBS, AEPS, OVA, OVA+AEPS, or OVA+Alum. Results provide insight to explore the potential role of mRNAs and lncRNAs in adjuvant-induced innate immune response.

ORGANISM(S): Mus musculus

PROVIDER: GSE124938 | GEO | 2021/01/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome profile of peritoneal lavage in response to adjuvants Alum and the polysaccharide from the roots of Actinidia eriantha (AEPS)

Project description:Transcriptome profile of peritoneal lavage in response to adjuvants Alum and the polysaccharide from the roots of Actinidia eriantha (AEPS)

| PRJNA514364 | ENA

Transcriptome profile in RAW264.7 cells in response to the polysaccharide from the roots of Actinidia eriantha (AEPS)

Project description:Recent studies have reported the activation of macrophages by the polysaccharide from the roots of Actinidia eriantha (AEPS). This study aims to explore the potential role of mRNAs and lncRNAs in AEPS-activated macrophages.

2018-10-05 | GSE120832 | GEO

RNA-seq of DRG neurons isolated from alum vs. alum+KLH immunized mice

Project description:Purpose: we have performed RNA-seq analysis of sensory neurons isolated from alum vs. alum+KLH immunized mice

2018-03-19 | GSE108428 | GEO

Control and Linc-AAM (a lincRNA associated with activated macrophages) knockdown RAW264.7 cells expression profiling under AEPS (the polysaccharide from the roots of Actinidia eriantha) stimulation

Project description:To gain an understanding of Linc-AAM function, we performed transcriptome analysis with microarray using Linc-AAM kncockdown RAW264.7 cells or control cells with or without AEPS treatment

2018-10-04 | GSE120788 | GEO

Characterizing adjuvants’ effects at the murine immunoglobulin repertoire level

Project description:We developed an improved library prep protocol and standardized the data analysis pipeline for accurate repertoire profiling. In addition, two metrics were implemented to assess repertoire clone properties. We then studied systemically the effects of two adjuvants, CpG and Alum, on the Ig heavy chain repertoire using the ovalbumin (OVA) challenged mouse model. Ig repertoires of different tissues (spleen and bone marrow) and isotypes (IgG and IgM) were examined and compared in terms of sequence mutation frequency, IGHV gene usage, CDR3 length, rescaled Hill numbers for clonal diversity, and clone selection strength. As a result, Ig repertoires of different tissues or isotypes exhibited distinguishable profiles at the non-immunized steady state. Adjuvanted immunizations further resulted in statistically significant alterations in Ig repertoire compared with PBS or OVA alone immunized groups. Lastly, we applied unsupervised machine learning techniques – multiple factor analysis and clustering – to identify Ig repertoire signatures in different compartments and under varying immunizations.

2023-04-07 | GSE228856 | GEO

Transcription profiling of mice treated with varying concentrations of ovalbumin (see also E-TIGR-133 and E-TIGR-134)

Project description:For each strain, Ova-alum and alum-only sensitization is followed by ovalbumin challenge. Reactivity measured at 24, 48, 72 hrs for each group is compared to an ova-pre-control sample.

2007-02-13 | E-TIGR-132 | biostudies-arrayexpress

Transcription profiling of mice treated with varying concentrations of ovalbumin (see also E-TIGR-132 and E-TIGR-134)

2007-02-13 | E-TIGR-133 | biostudies-arrayexpress

Transcription profiling of mice treated with varying concentrations of ovalbumin (see also E-TIGR-132 and E-TIGR-133)

2007-02-12 | E-TIGR-134 | biostudies-arrayexpress

miRNA chronic OVA aerosol

Project description:specific pathogen-free female BALB/c mice aged 7-8 weeks (Animal Resources Centre, Perth, Western Australia) were systemically sensitised by intraperitoneal injection of 50 M-5g of alum-precipitated chicken egg OVA (Grade V, ?98% pure, Sigma Australia) 21 and 7 days before inhalational challenge, then exposed to aerosolised OVA in a whole body inhalation exposure chamber (Unifab Corporation, Kalamazoo, MI). Chronic low-level challenge involved exposure to ?3 mg/m3 aerosolised OVA for 30 minutes/day on 3 days/week for up to 6 weeks. Particle concentration within the chamber was continuously monitored using a DustTrak 8520 instrument (TSI, St Paul, MN). All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of the University of New South Wales (reference numbers: 06/119B and 08/09B). Mice were sacrificed after 1,2,4 and 6 weeks of OVA exposure. Control groups included naM-ove mice and mice that were not sensitised but were challenged for 6 weeks with aerosolised OVA.

2011-06-10 | E-MEXP-3118 | biostudies-arrayexpress

RNA-seq of DRG neurons isolated from alum vs. alum+KLH immunized mice

Project description:RNA-seq of DRG neurons isolated from alum vs. alum+KLH immunized mice

| PRJNA427271 | ENA