Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus
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ABSTRACT: SLE patients exhibit increased interferon signatures in their skin secondary to increased production and a robust, skewed IFN response that is regulated by PITX1. Targeting of these exaggerated pathways may prove to be beneficial to prevent and treat hyperinflammatory responses in SLE skin.
ORGANISM(S): Homo sapiens
PROVIDER: GSE124939 | GEO | 2019/01/15
REPOSITORIES: GEO
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