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Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125145 | GEO | 2022/01/01

REPOSITORIES: GEO

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Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [ChIP-Seq]

Project description:Human neural crest cell development progresses via a pre-neural border (pNB) cell state that precedes the induction of the neurectoderm and the neural border. Here, we identify a set of pNB gene candidates, including forkhead box B1 (FOXB1), and their associated enhancers, that are rapidly activated by β-catenin-mediated signaling during human embryonic stem (ES) cell differentiation towards neural crest cells. FOXB1 simultaneously maintains neuroectoderm competency and controls the timing of differentiating ES cells to acquire neural crest fate by directly targeting key neural crest and neural progenitor loci in a context-dependent manner. Notably, the transient expression of FOXB1 in pre-neural crest cells also establishes autonomic neurogenic potential in mature neural crest cells, likely via its regulation of the expression of ASCL1, a master regulator of autonomic neurons. Altogether, our data implicates pNB cell state as the missing link bridging the exit of pluripotency to the acquisition of neural crest fate and its diverse ecto-mesenchymal differentiation potentials.

2022-01-01 | GSE125143 | GEO

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 3]

2022-01-01 | GSE125142 | GEO

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 2]

2022-01-01 | GSE125141 | GEO

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 1]

2022-01-01 | GSE125140 | GEO

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells

Project description:Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells

| PRJNA515314 | ENA

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [ChIP-Seq]

Project description:Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [ChIP-Seq]

| PRJNA515318 | ENA

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 2]

Project description:Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 2]

| PRJNA515320 | ENA

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 3]

Project description:Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 3]

| PRJNA515319 | ENA

Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 1]

Project description:Forkhead Box B1 regulates the differentiation timing and neurogenic potential of human neural crest cells [RNA-Seq 1]

| PRJNA515321 | ENA

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.

Project description:The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription factors specifically regulating terminal differentiation remain largely unknown. Using a RNA-sequencing (RNA-seq) profiling approach, we found that forkhead box c 1 (FOXC1) was significantly up-regulated in human normal primary KC during the course of differentiation. This observation was validated in human normal primary KC from several different donors and human skin biopsies. Silencing FOXC1 in human normal primary KC undergoing differentiation led to significant down-regulation of late terminal differentiation genes markers including epidermal differentiation complex genes, keratinization genes, sphingolipid/ceramide metabolic process genes and epidermal specific cell-cell adhesion genes. We further demonstrated that FOXC1 works down-stream of ZNF750 and KLF4, and upstream of GRHL3. Thus, this study defines FOXC1 as a regulator specific for KC terminal differentiation and establishes its potential position in the genetic regulatory network.

| S-EPMC5132327 | biostudies-literature

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