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Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE125149 | GEO | 2019/11/04

REPOSITORIES: GEO

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Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

Project description:In this study, use of a gene-targeted mouse model that is defective for pRb-condensin II interactions, Rb1L, has revealed instances where condensin II localization in interphase nuclei is dependent on pRb. Condensin II binding overlaps significantly with marks of active chromatin, and is enriched at the promoters of genes, including closely spaced divergent promoters. Interestingly, there are some bidirectional promoters where condensin II binds in an pRb-dependent manner and transcription of only one of the two genes is upregulated in Rb1L/L MEFs, suggesting the pRb-condensin II complex may be acting as a repressor or an insulator at distinct genomic locations to influence transcription. Chromatin conformations at these locations demonstrated that the pRb-condensin II complex may be responsible for maintaining more static, long-range interactions. In addition, pRb also recruits TFIIIC, another condensin II interactor, to many genomic loci. These recently discovered non-canonical transcriptional functions of the pRb-condensin II complex may represent an additional mechanism of pRb-mediated tumor suppression.

2019-11-04 | GSE125148 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

2019-11-04 | GSE125147 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

2019-11-04 | GSE125139 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

2019-11-04 | GSE125127 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

| PRJNA515324 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

| PRJNA515326 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

| PRJNA515327 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

| PRJNA515313 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

| PRJNA515322 | ENA

An RB-Condensin II Complex Mediates Long-Range Chromosome Interactions and Influences Expression at Divergently Paired Genes.

Project description:Interphase chromosomes are organized into topologically associated domains in order to establish and maintain integrity of transcriptional programs that remain poorly understood. Here, we show that condensin II and TFIIIC are recruited to bidirectionally transcribed promoters by a mechanism that is dependent on the retinoblastoma (RB) protein. Long-range chromosome contacts are disrupted by loss of condensin II loading, which leads to altered expression at bidirectional gene pairs. This study demonstrates that mammalian condensin II functions to organize long-range chromosome contacts and regulate transcription at specific genes. In addition, RB dependence of condensin II suggests that widespread misregulation of chromosome contacts and transcriptional alterations are a consequence of RB mutation.

| S-EPMC6944469 | biostudies-literature

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