Transcriptomics

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Nano genome altas (NGA) of body wide tissue specific responses


ABSTRACT: Purpose: In order to detect the unpredictable risks of the cumulative nanoparticles infiltrated everywhere in the whole body after systematic administration Methods: By using RNA-seq, we systematically studied the transcriptomic response of multi-organs from mice and tissue specific (stem) cells to the hydroxyapatite (HA) nano-delivery system. Results: We show that HA could differentially influence gene expression, immune response, cell proliferation, stress, apoptosis, metabolic, ion transport activity, cell signaling and epigenetic activity across tissues and tissue specific (stem) cells.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE125742 | GEO | 2019/03/29

REPOSITORIES: GEO

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