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α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE126089 | GEO | 2019/02/06

REPOSITORIES: GEO

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?1ACT Is Essential for Survival and Early Cerebellar Programming in a Critical Neonatal Window.

Project description:Postnatal cerebellar development is a precisely regulated process involving well-orchestrated expression of neural genes. Neurological phenotypes associated with CACNA1A gene defects have been increasingly recognized, yet the molecular principles underlying this association remain elusive. By characterizing a dose-dependent CACNA1A gene deficiency mouse model, we discovered that ?1ACT, as a transcription factor and secondary protein of CACNA1A mRNA, drives dynamic gene expression networks within cerebellar Purkinje cells and is indispensable for neonatal survival. Perinatal loss of ?1ACT leads to motor dysfunction through disruption of neurogenesis and synaptic regulatory networks. However, its elimination in adulthood has minimal effect on the cerebellum. These findings shed light on the critical role of ?1ACT in facilitating neuronal development in both mice and humans and support a rationale for gene therapies for calcium-channel-associated cerebellar disorders. Finally, we show that bicistronic expression may be common to the voltage-gated calcium channel (VGCC) gene family and may help explain complex genetic syndromes.

| S-EPMC6533132 | biostudies-literature

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

Project description:Previous study has shown that alpha1ACT is a transcription factor involved with regulating neuronal gene expression. We further performed ChIP-seq using pc12 cell lines stably expressing pcDNA3-alpha1ACT or control pcDNA3 vectors to identify genomic locus directly occupied by alpha1ACT

2019-02-06 | GSE126088 | GEO

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

Project description:Previous study has shown that alpha1ACT is a transcription factor involved with regulating neuronal gene expression. We performed a time-series RNA-seq study using pc12 cell lines stably expressing pcDNA3-alpha1ACT at 4 time points (6hr, 24hr, 3day, and 10day) to explore the transcriptional profiles that capture transient and prolonged dynamic changes regulated by alpha1ACT during cell cycle and differentiation

2019-02-06 | GSE126087 | GEO

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

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α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

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α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

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Neonatal Thyroxine Activation Modifies Epigenetic Programming Of The Liver

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DOCK8 is critical for the survival and function of NKT cells

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