Transcriptomics

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Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity


ABSTRACT: We provide a map of human ILC heterogeneity across multiple anatomical sites. Tissue-specific distinctions are particularly apparent for ILC1 populations, whose distribution was markedly altered in obesity or aging. Furthermore, the degree of ILC1 population hetero- geneity differed substantially in lymphoid versus mucosal sites. Together, these analyses comprise a comprehensive characterization of the spatial and temporal dynamics regulating the anatomical distri- bution, subset heterogeneity, and functional poten- tial of ILCs in non-diseased human tissues.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126107 | GEO | 2019/02/06

REPOSITORIES: GEO

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