Transcriptomics

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Negative regulation of lymphoid specification by the transcription factor Tal1


ABSTRACT: Lymphoid primed multipotent progenitors are a subset of MPPs that are undergoing specification to the lymphoid and myeloid cell fates. The transcription factors Lyl1 and E2A are both essential for the development LMPPs and can form a heterodimeric complex. We examined the consequences of E2A- or Lyl1-deficiency on development of LMPPs and on their gene expression program in comparison with wild-type LMPPs We used microarray data to examine the differences in gene expression between control, E2A-/- and Lyl1-/- CD138+ LSK cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE126148 | GEO | 2019/02/07

REPOSITORIES: GEO

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