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Human liver organoids; a patient-derived primary model for HBV Infection, Replication and Related Hepatocellular Carcinoma

ABSTRACT: Here we interrogate the potential of human liver organoids as a platform for modeling HBV infection and related tumorigenesis. We show that organoids derived from HBV-infected patients display an aberrant early cancer gene signature, which clusters with the HCC cohort on the TCGA LIHC dataset and away from healthy liver tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126798 | GEO | 2020/02/20

REPOSITORIES: GEO

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NEDD4-binding protein 1 suppresses HBV replication by regulating HBV RNAs

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