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Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses

ABSTRACT: Follicular T helper (T FH ) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult T FH cells at the transcriptomic level and demonstrate that the T FH cell program is well initiated in neonates although the T FH gene-expression pattern (i.e. CXCR5, IL-21, Bcl6, TBK1, STAT4, Ascl2 and c-maf) is largely underrepresented as compared to adult T FH cells. Importantly, we identified a dominant T H2 - bias of neonatal T FH cells, with preferential differentiation toward short-lived pre-T FH effector cells. Remarkably, adjuvantation with CpG-ODNs redirect neonatal pre-T FH cells toward committed GC-T FH cells, as illustrated by increased expression of T FH signature genes and reduced expression of T H2 -related genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE126843 | GEO | 2019/02/21

REPOSITORIES: GEO

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Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses

Project description:Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses

| PRJNA523446 | ENA

Regulation of follicular T-helper cell positioning and function by PD-1

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