Transcriptomics

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Mouse colon tumor gene expression of epithelial, stromal and infiltrating myeloid cells.


ABSTRACT: High T cell infiltration in colorectal cancer (CRC) correlates with a better disease outcome and immunotherapy response. This is observed in only a small subset of CRC patients. A better understanding of the factors influencing tumor T cell responses in CRC could inspire novel therapeutic approaches to achieve broader immunotherapy responsiveness. Numerous cell types and factors within the tumor microenvironment (TME) have been described as T cell suppressive within multiple mouse and human cancers. The influence of the TME on T cell infiltration and response in CRC is currently a matter of intense investigation. Here we investigated gene expression of different cell types isolated from mouse colon tumors or control tissue in order to find potential T cell suppressive cues present within these tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE126874 | GEO | 2019/10/29

REPOSITORIES: GEO

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