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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE127937 | GEO | 2020/04/19

REPOSITORIES: GEO

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [GATA3_ChIP-seq]

Project description:The goal of this study was to characterise the binding sites of GATA3 in human embryonic stem cells (hESCs) after exposure to the pro-differentiation growth factor BMP4.

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [SMAD_ChIP-seq]

Project description:The goal of this study was to characterise the binding sites of SMAD1 in cultured human embryonic stem cells (hESCs) immediately after exposure to the pro-differentiation growth factor BMP4.

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [scRNA-seq]

Project description:The goal of this study was to characterise transcriptional changes in single hESCs grown in a colony and treated with BMP4 to induce differentiation The goal of this study was to characterise transcriptional changes in single GATA3-/- hESCs grown in a colony and treated with BMP4 to induce differentiation

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation (RNA-seq data set 2)

Project description:The goal of this study was to characterise the earliest transcriptional changes that occur in human embryonic stem cells (hESCs) immediately after exposure to various pro-differentiation stimuli.

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation

Project description:Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [scRNA-seq]

Project description:Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [scRNA-seq]

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Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [SMAD_ChIP-seq]

Project description:Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [SMAD_ChIP-seq]

| PRJNA558139 | ENA

Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [GATA3_ChIP-seq]

Project description:Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation [GATA3_ChIP-seq]

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GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells.

Project description:During early development, extrinsic triggers prompt pluripotent cells to begin the process of differentiation. When and how human embryonic stem cells (hESCs) irreversibly commit to differentiation is a fundamental yet unanswered question. By combining single-cell imaging, genomic approaches, and mathematical modeling, we find that hESCs commit to exiting pluripotency unexpectedly early. We show that bone morphogenetic protein 4 (BMP4), an important differentiation trigger, induces a subset of early genes to mirror the sustained, bistable dynamics of upstream signaling. Induction of one of these genes, GATA3, drives differentiation in the absence of BMP4. Conversely, GATA3 knockout delays differentiation and prevents fast commitment to differentiation. We show that positive feedback at the level of the GATA3-BMP4 axis induces fast, irreversible commitment to differentiation. We propose that early commitment may be a feature of BMP-driven fate choices and that interlinked feedback is the molecular basis for an irreversible transition from pluripotency to differentiation.

| S-EPMC7487786 | biostudies-literature

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