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Genome-wide chromatin interaction maps of enhancer-promoter and promoter-promoter contacts in 5 leiomyoma (MED12 G44 mutant) and 5 matched normal myometrium (WT) patient tissue samples.

ABSTRACT: Through promoter capture Hi-C performed directly from patient tissue samples, we report the near-native characterization of intradomain chromatin architecture changes in uterine leiomyomas. This study identifies altered enhancer-promoter interactions and differential enhancer usage of enhancers associated with extracellular matrix-associated genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE128234 | GEO | 2020/01/01

REPOSITORIES: GEO

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