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Notch receptor expression in Trypanosoma cruzi infected Human Umbilical Vein Endothelial Cells treated with benznidazole or aspirin as revealed by microarray analysis

ABSTRACT: Chagas disease is a parasitic infection originally endemic to latinamerican countries but now spreaded worldwide that can be transmitted congenitally. Current specific therapy involves benznidazole, however, other therapies may modify gene expression that can change genetic expression profile, allowing cell programming to provide a more unfavorable environment for intracellular parasite development. Herein, microarray analysis was performed to Human Umbilical Vein Endothelial Cells (HUVEC), treated with benznidazole and the anti-inflammatory drugs aspirin or simvastatin, and infected with T. cruzi, the causative agent of Chagas disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE128270 | GEO | 2019/03/14

REPOSITORIES: GEO

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