Gene expression data from Melan-a cells expressing reduced level of Dicer and control Melan-a cells [24 hours]
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ABSTRACT: To investigate the molecular mechanism of the hypopigmentation observed in Dicer KO mice, Dicer knockdown was realised in vitro in normal C57BL/6 mouse melanocyte Melan-a cells. Transient transfection of Melan-a cells with siRNA directed against Dicer reduced Dicer protein levels to approximately 40% of that of siScr Melan-a cells 24 hours after transfection. We analyzed the transcriptome of Melan-a cells 24 hours after transfection with siDicer or siScr to understand the molecular mechanisms involved in Dicer-dependent melanocyte migration.
ORGANISM(S): Mus musculus
PROVIDER: GSE128755 | GEO | 2022/03/22
REPOSITORIES: GEO
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