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Comparison of chromatin accessibility between human and non-human primates

ABSTRACT: Evolution of transcriptional regulation is thought to be a major cause of the evolution of phenotypic traits. We compared DNase I Hypersensitive sites in fibroblast cells from five primates (human, chimpanzee, gorilla, orangutan, and macaque). We identified approximately 90,000 DHS sites, of which 59% are not significantly different between species, 27% are differential and likely due to a single evolutionary change, and 14% are differential and likely due to multiple changes. We found that including additional closely related species allows us to better distinguish between accessibility changes that are specific to a single species and those that have experienced changes in chromatin accessibility across multiple species during evolution.

ORGANISM(S): Gorilla gorilla Homo sapiens Pan troglodytes Pongo pygmaeus Macaca mulatta

PROVIDER: GSE129034 | GEO | 2019/10/11

REPOSITORIES: GEO

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