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Analysis of gene expression in colonic epithelial cells following DSS treatment

ABSTRACT: Mice with and without IFNAR expression were treated with broad-spectrum antibiotics for more than 10 days, either infected with MNV or left uninfected and then treated with 3% DSS in drinking water for 6 days. Intestinal epithelial cells were isolated from the colon and sorted and RNA extracted for RNASeq analysis. We found that mice with IFNAR expression on IEC and infected with MNV had a gene expression signature of DNA repair similar that induced by IL-22 signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE129384 | GEO | 2019/04/06

REPOSITORIES: GEO

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