DNA Methylation Identifies Genetically and Prognostically Distinct Subtypes of Myelodysplastic Syndromes
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ABSTRACT: We report the identification of five subtypes of myelodysplastic syndromes (MDS) identified via unsupervised classification of DNA methylation (DNAm) profiles. Bisulfite padlock probe sequencing (BSPP) was used to measure DNAm of ~500,000 unique CpGs covering 140,749 non-overlapping regulatory regions across the genome in bone marrow DNA samples from 141 patients with MDS. Application of a non-negative matrix factorization (NMF) decomposition of DNAm profiles identified five consensus clusters described by five NMF components as the most stable grouping solution.
ORGANISM(S): Homo sapiens
PROVIDER: GSE129828 | GEO | 2019/09/30
REPOSITORIES: GEO
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