Methylation profiling

Dataset Information

0

DNA Methylation Identifies Genetically and Prognostically Distinct Subtypes of Myelodysplastic Syndromes


ABSTRACT: We report the identification of five subtypes of myelodysplastic syndromes (MDS) identified via unsupervised classification of DNA methylation (DNAm) profiles. Bisulfite padlock probe sequencing (BSPP) was used to measure DNAm of ~500,000 unique CpGs covering 140,749 non-overlapping regulatory regions across the genome in bone marrow DNA samples from 141 patients with MDS. Application of a non-negative matrix factorization (NMF) decomposition of DNAm profiles identified five consensus clusters described by five NMF components as the most stable grouping solution.

ORGANISM(S): Homo sapiens

PROVIDER: GSE129828 | GEO | 2019/09/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-01-14 | GSE35896 | GEO
2013-01-14 | E-GEOD-35896 | biostudies-arrayexpress
2019-10-30 | PXD013609 | Pride
2011-11-23 | E-GEOD-30195 | biostudies-arrayexpress
2012-09-25 | E-GEOD-41130 | biostudies-arrayexpress
2016-06-30 | E-GEOD-81372 | biostudies-arrayexpress
2012-09-28 | E-GEOD-41215 | biostudies-arrayexpress
2016-06-30 | E-GEOD-81173 | biostudies-arrayexpress
2013-11-21 | E-GEOD-48153 | biostudies-arrayexpress
2013-11-21 | E-GEOD-48154 | biostudies-arrayexpress