Transcriptomics

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Transcriptional profiling of endothelial cells lacking Flvcr2


ABSTRACT: Flvcr2 is a putative heme transporter expressed in endothelial cells of the brain. Mutations in this gene in humans is the cause of Fowler syndrome, in which newborns show malformed brain blood vessels. We generated a mouse model of this disease by knocking out the mouse ortholog of the gene (Flvcr2). These mouse mutants recapitulate the human phenotype. To understand the molecular changes associated with Flvcr2 deletion, we defined the transcriptional profile of heterozygous and mutant endothelial cells. We observed changes in gene expression consistent with altered angiogenesis and metabolic pathways necessary for endothelium homeostasis.

ORGANISM(S): Mus musculus

PROVIDER: GSE129838 | GEO | 2020/05/06

REPOSITORIES: GEO

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