Transcriptomics

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Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits


ABSTRACT: Ablation of the ATRX chromatin remodeler specifically in forebrain excitatory neurons of mice causes male-specific deficits in long-term spatial memory associated with miR-137 overexpression, transcriptional changes and structural alterations corresponding to pre- and post-synaptic abnormalities.

ORGANISM(S): Mus musculus

PROVIDER: GSE129975 | GEO | 2020/06/30

REPOSITORIES: GEO

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