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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE130231 | GEO | 2019/07/15

REPOSITORIES: GEO

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

Project description:The Polycomb group of proteins is required for the proper orchestration of gene expression due to its role in maintaining transcriptional silencing. It is composed of several chromatin modifying complexes, including Polycomb Repressive Complex 2 (PRC2), which deposits H3K27me2/3. Here, we report the identification of a cofactor of PRC2, EZHIP (EZH1/2 Inhibitory Protein), expressed predominantly in the gonads. EZHIP limits the enzymatic activity of PRC2 and lessens the interaction between the core complex and its accessory subunits, but does not interfere with PRC2 recruitment to chromatin. Deletion of Ezhip in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Our results suggest that mature oocytes Ezhip-/- might not be fully functional and indicate that fertility is strongly impaired in Ezhip-/- females. Altogether, our study uncovers EZHIP as a regulator of chromatin landscape in gametes.

| S-EPMC6710278 | biostudies-literature

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (RNA-Seq)

Project description:We identified a novel cofactor of PRC2, expressed predominantly in the gonad, that limits PRC2 enzymatic activity by impeding the interaction between the core complex and the accessory subunits.

2019-07-15 | GSE130229 | GEO

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq)

Project description:We identified a novel cofactor of PRC2, expresesd predominantly in the gonad, that lmits PRC2 enzymatic activity by impeding the interaction between the core complex and its accessory subunits.

2019-07-15 | GSE130230 | GEO

GPIF constrains Polycomb Repressive Complex 2 activity in germ cells

Project description:The project aimed at identifying the cofactors regulating Polycomb complex PRC2 enzymatic activity in gonads. We used a knock-in mouse model where the enzymatic subunit of PRC2 (either EZH2 or EZH1) is tagged (Flag-tag) to purify PRC2 from mouse adult testis. This experiment revealed the existence of a new cofactor for PRC2 that we called GPIF (AU022751).

2019-07-22 | PXD012354 | Pride

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

Project description:EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

| PRJNA534322 | ENA

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (RNA-Seq)

Project description:EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (RNA-Seq)

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EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq)

Project description:EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq)

| PRJNA534326 | ENA

LATS2 regulates repressive epigenetic integrity via regulation of Polycomb repressive complex 2

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-25 | E-GEOD-63538 | biostudies-arrayexpress

Role of polycomb repressive complex 1 in the intestinal homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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