Transcriptomics

Dataset Information

0

Gene expression in a mouse model of Pantothenate Kinase-Associated Neurodegeneration


ABSTRACT: A mouse model lacking systemic expression of Pank1 together with neuronal deletion of Pank2 was generated and revealed a developmental requirement for CoA that, when deficient, resulted in abnormal motor behavior preceding early death. Neuronal Pank2 expression in Pank1-/-Syn-Pank2-/- double knockout mice (dKO) decreased starting at P9-11 and brain CoA levels did not increase subsequently, in contrast to wild-type matched control animals. The Pank1-/-Syn-Pank2-/- dKO mice developed a forelimb deformity and abnormal gait behavior, similar to PKAN patients, and lost weight when brain CoA became depressed relative to wild-type levels. Comparative gene expression analysis revealed significant alteration of a relatively small selection of genes, including reduction of gene transcripts affecting heme and hemoglobin synthesis together with upregulation of gene transcripts related to the response to oxygen/glucose deprivation.

ORGANISM(S): Mus musculus

PROVIDER: GSE130705 | GEO | 2020/01/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2015-05-27 | E-GEOD-57990 | biostudies-arrayexpress
2024-11-06 | GSE244050 | GEO
2020-01-15 | GSE142416 | GEO
2022-08-29 | GSE147460 | GEO
2022-05-22 | GSE131712 | GEO
2015-09-07 | PXD002259 | Pride
2015-09-07 | PXD002263 | Pride
2015-09-07 | PXD002262 | Pride
2015-09-07 | PXD002257 | Pride
2015-09-07 | PXD002258 | Pride