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RtcB RNAseq to map cyclic phosphate-bearing RNA fragments during poly I:C treatment

ABSTRACT: RNase L is activated by 2-5A, which is synthesized specifically upon dsRNA sensing. Activated RNase L cleaves cellular RNAs, generating fragments that bear 2'-3' cylic phosphate and/or 5'-OH. Here we perform cyclic-phosphate capture and RNA-seq to map the precise sites at which cleavage is induced during dsRNA stress.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131130 | GEO | 2019/05/14

REPOSITORIES: GEO

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