Transcriptomics

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Expression data from 3T3-MEFs derived from wild-type and SMRT RID mutant mice


ABSTRACT: SMRT (silencing mediator of retinoid and thyroid hormone receptors) is recruited by numerous transcription factors to mediate lineage and signal dependent transcriptional repression. We generated a knock-in mutation in the receptor interaction domain (RID) of SMRT (SMRTmRID) that solely disrupts its interaction with nuclear hormone receptors. SMRTmRID-derived 3T3-MEFs display a dramatically increased adipogenic capacity and accelerated differentiation rate. We measured global gene expression in wild-type versus SMRTmRID-derived 3T3-MEFs in the undifferentiated state to examine which pathways were altered. Our results demonstrate that SMRT-RID dependent repression is a key determinant of the adipogenic set point. Keywords: SMRTmRID expression compared to wild-type

ORGANISM(S): Mus musculus

PROVIDER: GSE13143 | GEO | 2009/01/07

SECONDARY ACCESSION(S): PRJNA109577

REPOSITORIES: GEO

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