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Comparison of human CD39- and CD39+ thymus-derived regulatory T-cells

ABSTRACT: CD39- and CD39+ human thymus-derived regulatory T-cells (tTreg) present as distinct subsets with specific functional and metabolic response patterns. Both cell types express equal levels of the canonical tTreg transcription factors FOXP3 and Helios and overexpression studies have shown that CD39 expression is independent of these two transcription factors. So far, no transcriptomic analyses to adress these differences have been performed. We used microarrays to detail the global programme of gene expression between CD39- and CD39+ human tTreg and identified distinct classes of up-regulated and down-regulated genes between these two subsets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE131743 | GEO | 2020/07/02

REPOSITORIES: GEO

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