Expression data from isoalted adult cardiomyocytes w/o Isopretrenol stimulation.

ABSTRACT: Sympathetic activation of β-adrenergic receptors (β-AR) represent a hallmark in the development of heart failure (HF). Genome-wide analysis of CaMKII-mediated H3S28p in response to chronic β-AR stress by chromatin-immunoprecipitation followed by massive genomic sequencing led to the identification of CaMKII-dependent H3S28p target genes.40 % of differentially H3S28p-enriched genomic regions were associated with differential, mostly increased expression of the nearest genes, pointing to CaMKII-dependent H3S28p as an activating histone mark.

ORGANISM(S): Mus musculus

PROVIDER: GSE131796 | GEO | 2019/11/11

REPOSITORIES: GEO