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Genome-wide profilings of chromatin accessibility and transcriptomes during different stages of G0 in fly wings

ABSTRACT: Cell cycle exit is usually enforced during terminal differentiation in various organisms and tissues. To understand how this is achieved molecularly, we exained the genome-wide profiles of chromatin accessibility and transcriptomes at normal development stages of fly wings as well as situations where we uncoupled cell cylce exit from terminal differentiation with genetic manipulations. We found that developmentally programmed, temporal changes in chromatin accessibility at a small subset of critical cell cycle genes act to enforce cell cycle exit during terminal differentiation.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE131981 | GEO | 2019/05/31

REPOSITORIES: GEO

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